Vimovo is a pain medication that contains naproxen and esomeprazole, the active ingredient in Nexium. Recent studies have suggested that long-term use of Nexium and other proton pump inhibitors may be associated with an increased risk of chronic kidney disease and kidney failure.
Vimovo is used to treat symptoms associated with:
Naproxen is an NSAID pain reliever that works by reducing substances in the body that cause inflammation, pain, and fever. Esomeprazole is a proton pump inhibitor that decreases the amount of acid produced by the stomach. It helps help reduce the risk of stomach ulcers in people who may be at risk for them while taking an NSAID.
The Vimovo prescribing information includes a Black Box Warning regarding the following:
Vimovo is a tablet that is taken twice per day. It should be used at the lowest effective dose for the shortest time possible.
Side effects commonly associated with Vimovo include upset stomach, stomach pain, heartburn, nausea, gas, diarrhea, constipation, drowsiness, or dizziness. Patients should contact their doctor if they experience:
Serious Vimovo side effects may include:
Proton pump inhibitors, including esomeprazole, have been linked to acute interstitial nephritis, a sudden inflammation of the kidney tubules that can progress to kidney disease and renal failure if not recognized and treated. The condition is usually associated with a hypersensitivity reaction to a medication. Symptoms may include:
In 2016, two studies found possible links between the long-term use of proton pump inhibitors and serious kidney complications:
In July 2016, the journal Reactions Weekly detailed the case of 44-year-old Vimovo patients who developed a wide range of serious side effects, including kidney failure, while using the medication. “Over the course of a week, his clinical situation deteriorated with worsening renal function and appearance of a widespread rash. His abdominal pain also became more distressing and he mounted a severe inflammatory response, renal failure and liver impairment with significant oedema,” his doctors wrote. A kidney biopsy later confirmed severe eosinophilic interstitial nephritis and mesangial glomerulonephritis. Read More
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