PrevAcid Kidney Inflammation (Nephritis)

Acute interstitial nephritis is a sudden form of kidney inflammation that can affect people taking PrevAcid. If not recognized and treated, the condition may progress to kidney disease and renal failure.

PrevAcid and Acute Interstitial Nephritis

Proton pump inhibitors like PrevAcid can contribute to the development of acute interstitial nephritis, a condition characterized by a sudden inflammation of the kidney tubules. In fact, one study from 2014 found that these heart burn medications were the most common cause of the condition in an outpatient setting.

In 2014, the U.S. Food & Drug Administration (FDA) added information about nephritis to the labels of all prescription proton pump inhibitors, including PrevAcid. The agency did so in response to a petition filed by Public Citizen that demanded stronger warnings and patient medication guides for the entire class of heart burn drugs. However, reports of patients who developed the condition while using proton pump inhibitors began appearing in the medical literature as early as 1992 . Read More.

  • 1992: A case of acute interstitial nephritis related to the use of a proton pump inhibitor was published in the American Journal of Medicine.
  • 1994: AstraZeneca disclosed that at least 15 cases of kidney inflammation had been reported worldwide in people using a proton pump inhibitor called Nexium.
  • 2005: Two additional cases of nephritis were reported by Austrian researchers, including one in which a 63-year-old man developed nephritis after using a proton pump inhibitor for just three weeks. The second patient required long-term dialysis.
  • 2015: Research published in CMAJ Open suggested that seniors who began treatment with proton pump inhibitors were three times more likely to develop nephritis or other kidney complications compared to their peers who did not take the medications.

PrevAcid Nephritis: Symptoms and Treatment

Interstitial nephritis can cause mild to severe kidney problems. About 50% of those affected experience decreased urine output. Other symptoms may include:

  • Blood in the urine
  • Fever
  • Increased or decreased urine output
  • Mental status changes (drowsiness, confusion, coma)
  • Nausea, vomiting
  • Rash
  • Swelling of the body, any area
  • Weight gain (from retaining fluid)

When a drug such as PrevAcid is suspected to be the cause of acute kidney inflammation, cessation of the medication may alleviate symptoms. In serious cases, dialysis may be required for a period of time. Anti-inflammatory drugs, such as corticosteroids, can be helpful.

Complications associated with nephritis include metabolic acidosis, chronic kidney failure and end-stage kidney disease. Older people are more likely to experience these serious problems.

  1. Renal and Neurology News (2014) “PPI-Induced Acute Interstitial Nephritis May Be On the Rise”
  2. FDA (2015) “Prevacid (lansoprazole) Delayed-Release Capsules and Prevacid Solutab (lansoprazole) Delayed-Release Orally Disintegrating Tablets”
  3. American Journal of Medicine (1992) “Acute interstitial nephritis due to omeprazole.”
  4. The Medical Journal of Australia (2005) “Acute interstitial nephritis secondary to esomeprazole”
  5. HealthLine (N.D.) “Interstitial Nephritis”
Last Modified: June 8, 2016

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